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New directions for enhanced 13C imaging of brain cancer. Immunocytochemical stain for the hypoxia-induced factor (HIF)-1α indicates glioblastoma to be particularly rich in this cancer biomarker protein. This may, in the future, provide a uniquely sensitive means of in vivo imaging of brain cancer grade and metabolic activity (see Fig 13). RENCA, renal cancer; A-20-A (top left, top right, and bottom right ×160; bottom left ×312). (Courtesy of Dr. Ashraf Imam).
