Fig 3.

¹³C MR spectroscopy of neuronal function in the frontal brain. To obtain equivalent data concerning neuronal function, the isotope infused must be C2-enriched ¹³C glucose which, in contrast to carbon 1 (C1)-glucose, enriches glutamate and glutamine in C5 and C1 (left panel). These products can safely be measured with a low-power NOE method in the frontal lobes (right panel). PCr indicates phosphocreatine. Reproduced with permission from Radiology.⁴ Copyright 2009, Radiological Society of North America.