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. 2010 Jan;31(1):170–174. doi: 10.3174/ajnr.A1782

Table 1:

Characteristics of included studiesa

Article Year Journal Study Type rtPA Dose/NINDS Site of Occlusion Recan. Assessment Tool Recan. Times No. of Patients With Recan. Total No. of Relevant Patients
Noncontrast Studiesb
    Alexandrov et al 2004 Stroke Prospective cohort Yes <180 min M1, M2 TCD 2 h (Post-rtPA) 73 120
    Daffertshofer et al 2005 Stroke NRCT Yes <360 min ICA, M1, M2, M3 MRA 24 h 10 26
    Derex at al 2004 Neuroradiology Prospective cohort No <360 min ICA, M1, M2, ACA MRA 24 h 28 47
    Eggers at al 2003 Ann Neurol RCT Yes <180 min M1, M2 TCD 1 h (Post-rtPA) 8 25
    Gerriets et al 2002 Stroke RCT (substudy of DIAS 1) Yes <360 min ICA, M1, M2 TCD 24 h 8 11
    Kwon et al 2004 Arch Neurol Retrospective cohort Yes <360 min ICA, MCA MRA 72 h 14 20
    Molina et al 2001 Stroke Case control Yes <180 min M1, M2 TCD 48 h 22 24
    Neumann-Haefelin et al 2004 Stroke Retrospective cohort NS <360 min M1 MRA 24 h 18 52
    Rubiera et al 2006 Stroke Prospective cohort Yes <360 min ICA, M1, M2 TCD 2 h (Post-rtPA) 141 219
    Savitz et al 2005 Stroke Retrospective cohort Yes <360 min ICA, MCA MRA 72 h 27 37
    Sekoranja et al 2006 Stroke Prospective cohort Yes <180 min ICA, MCA TCD 30 min (Post-rtPA) 17 33
    Yasaka et al 1998 Neurology RCT No 210 ± 36 min MCA; origin, trunk, distal TCD 24 h 8 8
Contrast Contrast studiesb
    Muir et al 2005 JNNP Prospective cohort Yes <200 min M1, M2 CTA, TCD, DSA 48 h 9 12
    Murphy et al 2006 Stroke Prospective cohort NS <420 min MCA syndrome CTA 24 h 4 7
    Wintermark et al 2006 Stroke Prospective cohort No <420 min Large-artery occlusion MRA 2–7 d 28 41
    von Kummer et al 1995 Stroke Prospective cohort No <360 min ICA, M1, M2 DSA Immediately post-rtPA 19 61
    Sasaki et al 1996 AJNR Prospective cohort No <480 min M1, M2 DSA 24 h 1 3
    Mori et al 1992 Neurology RCT No <360 min ICA, M1, M2, AM DSA Immediately post-rtPA 9 19

Note:—Recan. indicates recanalization, JNNP, J Neurol Neurosurg Psychiatry; RCT, randomized controlled trial; NRCT, non-randomized controlled trial; CTA, CT angiography; DSA, digital subtraction angiography; MRA, MR angiography; TCD, transcranial Doppler sonography; ICA, internal carotid artery; ACA, anterior cerebral artery; MCA, middle cerebral artery; M1, M1 branch of the MCA; M2, M2 branch of the MCA; M3, M3 branch of the MCA; AM, A2 branch of the ACA; NS, not specified; rtPA, recombinant tissue plasminogen activator; DIAS I, Desmoteplase in Acute Ishemic Stroke Trial; NINDS, National Institute of Neurological Disorders and Stroke.

a

Included are data indicating whether rtPA was administered as per the protocol used in the NINDS trial.24

b

All studies are listed in on-line Fig 1.