Table 5.
The kinase target networks of CXC chemokines in OC (LinkedOmics).
| CXC chemokines | Enriched kinases target | Description | Leading EdgeNum | p-value |
|---|---|---|---|---|
| CXCL1 | Kinase_PLK1 | Polo-like kinase 1 | 33 | 0 |
| Kinase_ATM | ATM serine/threonine kinase | 68 | 0 | |
| CXCL3 | Kinase_ATM | ATM serine/threonine kinase | 52 | 0 |
| Kinase_CDK2 | Cyclin-dependent kinase 2 | 106 | 0 | |
| CXCL8 | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 20 | 0 |
| Kinase_ATM | ATM serine/threonine kinase | 40 | 0 | |
| CXCL9 | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 17 | 0 |
| Kinase_FYN | FYN proto-oncogene, Src family tyrosine kinase | 14 | 0 | |
| CXCL10 | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 23 | 0 |
| Kinase_LYN | LYN proto-oncogene, Src family tyrosine kinase | 17 | 0 | |
| CXCL11 | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 21 | 0 |
| Kinase_LYN | LYN proto-oncogene, Src family tyrosine kinase | 18 | 0 | |
| CXCL12 | Kinase_LYN | LYN proto-oncogene, Src family tyrosine kinase | 19 | 0 |
| Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 21 | 0 | |
| CXCL13 | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 21 | 0 |
| Kinase_FYN | FYN proto-oncogene, Src family tyrosine kinase | 14 | 0 | |
| CXCL14 | Kinase_ATR | ATR serine/threonine kinase | 39 | 0 |
| Kinase_ATM | ATM serine/threonine kinase | 44 | 0 | |
| CXCL16 | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 27 | 0 |
| Kinase_LYN | LYN proto-oncogene, Src family tyrosine kinase | 24 | 0 | |
| CXCL17 | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 20 | 0 |
| Kinase_LYN | LYN proto-oncogene, Src family tyrosine kinase | 21 | 0 |