Effects of brain irradiation on brain water content and BBB permeability. A, Water content of brain, determined by the method of dry and wet weight. Water content in brain = (wet weight−dry weight)/wet weight × 100%. B, BBB permeability was expressed as micrograms of EB per milligrams of brain tissue (μg/g). * P < .05, ** P < .01, # P < .001, compared with their corresponding sham.