Table 1:
Demographic dataa
| Control | Premanifest | Early HD | |
|---|---|---|---|
| (n = 20) | (n = 21) | (n = 40) | |
| Gender (M:F) | 7:13 | 10:11 | 20:20 |
| Age (yr) | 44.9 (10.5) | 37.2 (7.9) | 48.5 (9.6) |
| CAG repeat length | NA | 42.2 (1.8), range, 40–45 | 43.7 (2.4), range, 40–50 |
| Predicted years to onsetb | NA | 18.2 (7.1), range, 9–35 | NA |
| Disease duration (yr since onset) | NA | NA | 4.1 (2.6) |
| UHDRS motorc | 1.1 (0.9) | 3.6 (4.0) | 28.9 (12.6) |
| UHDRS independenced | 100 (0) | 100 (0) | 90.4 (9.6) |
| UHDRS TFCe | 13 (0) | 13 (0) | 10.9 (1.8) |
a
Data are mean (SD) with the exception of gender and handedness.
b
Onset was defined as a 60% chance of showing motor signs (a greater chance of showing signs than not, as described in Feigin et al30) and was predicted using the equation of Langbehn et al.31
c
UHDRS motor is out of 124; higher score indicates more severely impaired.
d
Independence is a percentage; higher score indicates better function.
e
TFC is out of 13; higher score indicates better function.