Fig 4.

Example of treatment-related necrosis by using 2 different AUC measurements. A, An enhancing lesion on T1WI of the left frontal lobe, which was proved to be treatment-related necrosis (pathology grade = 5). B, A slow progressive increase in signal of the lesion compared with the vascular input and the lesion in B. C and D, the “intermediate AUC” and “delayed short AUC” integrations, respectively. Notice the significant drop in the superior sagittal sinus between these integrations (312 to 219 relative units) with little change in the lesion (it remains at 28). Intermediate and delayed short AUC values from these data are 9% (28/312) and 12% (28/219), respectively.