Significance of measurements. A, Significance of ONS volume. Bar graph shows significant differences of mean ONS volumes and corresponding ranges of patient and control groups. B, Significance of OS volume. Note a tendency toward an increased mean OS volume in patients with IIH compared with controls, which, however, does not reach statistical significance. C, Significance of hypophysis volume. This bar graph clearly shows significantly lower mean volumes of hypophysis in patients compared with controls.