Fig 1.

Concentration-time curve. Peak enhancement: maximal concentration of contrast agent with time: Peak = $\underset{t}{\max }$ C(t). Time-to-peak enhancement: the time needed for the contrast agent to reach its maximum concentration: TTP = arg $\underset{t}{\max }$ C(t). Wash-in: initial upslope of the concentration-time curve (slope from the end of the baseline to the peak of the curve). Washout: down-slope of the concentration time curve (negative slope from the peak to the last acquisition time point). ΔSI indicates change in signal intensity.