Neuroimaging features comparing lobar versus septopreoptic HPE

	Lobar	Septopreoptic
Cortical nonseparation	Basal frontal	Septal and preoptic regions
CC	Rostrum and genu absent; anterior body variably present; splenium present	Rostrum absent or hypoplastic; genu hypoplastic; body and splenium present
Anterior interhemispheric fissure and falx	Hypoplastic anteriorly	Fairly deep IHF
Ventricles	Rudimentary frontal horns; third ventricle formed	Normal or small frontal horns; third ventricle formed
Dorsal cyst	Absent	Absent
SP	Absent	Present or dysplastic, rarely absent
Hypothalamus	Often fused to some degree (83%)	Anterior hypothalamus often fused
Cerebral vasculature	Azygous anterior cerebral artery (more anteriorly displaced)	Azygous anterior cerebral artery (more posteriorly placed)