Table 3.

Unadjusted outcome-wide association of exposome score for schizophrenia

Outcome variable	OR	95% CI	P	R 2
Extraversion	0.89	0.83–0.95	<.001	0.28
Poor eyesight	0.90	0.57–1.44	.666	0.05
High blood pressure	0.98	0.88–1.08	.652	0.01
Cancer	1.12	0.85–1.48	.429	0.09
Diabetes	1.13	0.97–1.32	.108	0.15
Thyroid abnormality	1.15	0.98–1.35	.097	0.18
Minor depressive disorder	1.15	0.98–1.35	.081	0.19
Heart disease	1.20	0.96–1.49	.105	0.27
Joint wear	1.20	1.06–1.36	.004	0.40
Back pain or hernia	1.25	1.11–1.40	<.001	0.61
Joint inflammation	1.26	1.09–1.46	.002	0.57
Alcohol abuse	1.32	1.22–1.43	<.001	1.31
COPD	1.35	1.17–1.57	<.001	1.01
Other physical problems	1.38	1.26–1.51	<.001	1.58
Migraine	1.39	1.23–1.58	<.001	1.34
Asthma	1.42	1.25–1.61	<.001	1.52
Intestinal disorder	1.49	1.23–1.80	<.001	1.62
Antisocial personality disorder	1.51	1.29–1.77	<.001	1.89
Ulcers	1.52	1.14–2.02	.005	1.51
Specific phobia	1.59	1.46–1.74	<.001	3.52
Panic disorder	1.59	1.42–1.79	<.001	2.93
Neuroticism	1.73	1.62–1.85	<.001	6.39
Generalized anxiety disorder	1.79	1.61–1.99	<.001	5.11
Major depressive disorder	1.80	1.68–1.93	<.001	7.03
Dysthymia	1.95	1.62–2.35	<.001	5.37
Alcohol dependence	1.95	1.67–2.29	<.001	5.77
Agoraphobia	1.99	1.69–2.34	<.001	6.04
Social phobia	2.01	1.85–2.18	<.001	8.79
Suicide attempt	2.24	1.95–2.57	<.001	9.46
Suicidal thoughts	2.39	2.19–2.60	<.001	13.58
Suicide plan	2.44	2.16–2.75	<.001	12.44
Bipolar disorder	2.61	2.19–3.10	<.001	13.01
Schizophrenia spectrum disorder	2.76	2.20–3.46	<.001	14.03

23 significant associations after Bonferroni correction (P < .05/33);

COPD, chronic obstructive pulmonary disease; R², Nagelkerke’s R².