Fig. 1.

Flow diagram of both patients and treatments with number of nonresponders to treatment (NRTT), partial responders to treatment (PRTT), and loss to follow-up. We recruited 142 schizophrenia (SCZ) patients treated with antipsychotic drugs during 2 trials with antipsychotic drugs. During the first trial, patients were treated for 8 weeks and after this trial divided into those without a clinical response (n = 84) and a partial response (n = 51) according to Clinical Global Impression Improvement (CGI-I) scores (loss to follow-up: n = 7). The partial responders continued to take the same medication for another 2 months, while we lost again 7 patients in the follow-up yielding a final PRTT study group of n = 55. The nonresponders to a first antipsychotic agent were switched to another antipsychotic treatment for another 8 weeks, and during this follow-up period, we lost 13 patients. Two months later, 11 patients showed a partial response to treatment. Finally, 55 PRTT or 60 NRTT according to CGI-I scores and Conley and Kelly²⁸ criteria participated in this study. CPZE, chlorpromazine equivalents mg/day.