Group characteristics for controls, premanifest HD groups A + B, and manifest HD groups 1 and 2a
| Controls | Premanifest A | Premanifest B | Manifest 1 | Manifest 2 | ||
|---|---|---|---|---|---|---|
| No. | 25 | 10 | 11 | 9 | 12 | |
| Age | Baseline | 48.3 (7.6) | 45.5 (5.2) | 42.9 (11.2) | 47.7 (11.8) | 50.9 (9.4) |
| CAG | Baseline | Baseline | 41.3 (1.3) | 44.0 (3.1) | 43.8 (3.5) | 43.2 (1.9) |
| YTO | Baseline | Baseline | 13.8 (3.8) | 8.4 (1.6) | N/A | N/A |
| TMS | Baseline | Baseline | 2.3 (1.7) | 3.0 (1.1) | 16.9 (8.8) | 26.2 (11.7) |
| Follow-up | 1.7 (1.4) | 6.0 (6.9) | 6.3 (2.5)b | 23.0 (9.0)b | 37.8 (14.3)b | |
| TFC | Baseline | 12.9 (0.2) | 12.7 (0.7) | 12.6 (0.9) | 12.0 (1.0) | 8.6 (1.2) |
| Follow-up | 12.8 ( | 12.5 (0.9) | 12.4 (1.2) | 11.2 (2.0) | 6.0 (3.3)b | |
| MMSE | Baseline | 29.2 (1.2) | 29.0 (1.2) | 28.4 (1.9) | 29.0 (0.9) | 26.5 (3.1) |
| Follow-up | 29.1 (1.2) | 29.3 (0.8) | 28.6 (1.7) | 28.7 (1.1) | 27.0 (3.9) | |
| SDMT | Baseline | 50.1 (9.6) | 52.7 (7.4) | 46.9 (12.0) | 42.0 (8.1) | 31.2 (11.1) |
| Follow-up | 51.5 (10.8) | 52.7 (9.5) | 48.3 (9.9) | 39.6 (10.7) | 27.9 (13.3) | |
| Stroop | Baseline | 99.8 (13.4) | 97.1 (10.5) | 86.9 (16.3) | 88.4 (13.6) | 69.4 (21.5) |
| Follow-up | 102.7 (16.9) | 92.5 (7.5) | 83.4 (19.3) | 89.8 (18.9) | 55.6 (22.6)b | |
| PBA | Baseline | 6.4 (8.4) | 6.7 (8.7) | 7.4 (7.1) | 11.7 (11.7) | 14.0 (11.8) |
| Follow-up | 6.6 (9.0) | 6.1 (11.9) | 7.8 (9.70 | 9.7 (11.7) | 22.6 (16.3) |
Note:—CAG indicates cytosine-adenosine-guanine–repeat length; YTO, expected years to disease onset; TMS, total motor score; TFC, total functional capacity; MMSE, Mini-Mental State Examination; SDMT, Symbol-Digit Modality Test; PBA, Problem Behavior Assessment; N/A = not applicable.
a
Values are mean (SD).
b
P < .005 significant longitudinal change.