Table 2:
List of studies that do not demonstrate depression of wheel running following pain
| Type of Pain |
Pain condition |
Species | Sex | Acquisition Period Prior to Pain |
Wheel in home cage? | Duration of assessment |
Reference |
|---|---|---|---|---|---|---|---|
| Inflammation | Formalin (2 paw) | Rat | M | 24 h/day for 3 days; 1 h/day for 4 days prior to injection | Yes, but locked for 23 h/day for 4 days prior to injection | 1 h | (Grace et al. 2014) |
| CFA (L1 dorsal dermatome) | |||||||
| Formalin (L1 dorsal dermatome) | |||||||
| Carrageenan (tail) | Rat | F | 4 days | Yes | 12 h | (Loram et al. 2007) | |
| CFA (1 paw) | Mouse | M | 1 hour/day for 3 days | No | 1 hour | (Cobos et al. 2012) | |
| CFA (tail) | Mouse | M | 0 days | Yes | 24 h/day | (Oto et al. 2019) | |
| Formalin (1 paw) | Mouse | M/F | - | No | - | (Ulker et al., 2020) | |
| Neuropathy | Spared Nerve Injury | Mouse | F | 2 h/day for 2 days | Yes, but locked for 22 h/day | 2 h | (Sheahan et al. 2017) |
| Migraine | Nitroglycerin | Rat | F | 2-3 days in group; 30 min sessions individually | No | 30 min | (Christensen et al. 2016) |
| Other | Antiretroviral-induced pain | Rat | F | 12 days | Yes | 24 h | (Weber et al. 2007) |
CFA: Complete Freund’s Adjuvant