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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Curr Opin Struct Biol. 2021 Jan 16;66:225–230. doi: 10.1016/j.sbi.2020.12.002

Figure 1: SOD1 trimer formation: on- or off-pathway.

Figure 1:

The formation of SOD1 trimers is unclear. One hypothesis is that the SOD1 trimer forms on-pathway from monomers, to native dimers (with the native dimer dissociating into monomers), to trimers, and then to large aggregates. The other hypothesis is that the formation of the trimer is off-pathway meaning it does not lead to the formation of large aggregates.