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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Curr Opin Struct Biol. 2021 Jan 16;66:225–230. doi: 10.1016/j.sbi.2020.12.002

Figure 3: SOD1 trimer-specific therapeutic strategies.

Figure 3:

Targeting SOD1 timers show therapeutic promise. Several proposed mechanisms discussed in this review are decreasing trimer stability, addressing glutamate toxicity due to trimers, and direct binding to sequester SOD1 oligomers with specific antibodies.