Imaging characteristics by time from last seen well to MRI

	0 to <3 Hours (n = 21)	3–6 Hours (n = 70)	0–6 Hours (Entire Cohort) (n = 91)	P Value (Difference, 0–3 vs 3–6)
Age (yr) (median) (IQR)	58 (54–77)	73 (63.25–83)	70 (59–82)	.034
NIHSS (median) (IQR)	13 (11–19)	17 (13–22.75)	17 (12–21.5)	.050
CT ASPECTS (median) (IQR)	9 (7–10)	8 (I6–9)	8 (6–9)	.202
CT ASPECTS ≥7 (No.) (%)	17/20 (85%)	42/61 (69%)	59/81 (72%)	.159
CTA collaterals >50% (No.) (%)	14/19 (74%)	37/57 (65%)	51/76 (67%)	.481
DWI volume (mL) (median) (IQR)	24.7 (13.9–63.8)	29.4 (12.1–68.5)	29.2 (12.3–68.5)	.906
MRI DWI volume ≥70 mL of DWI volume (No.) (%)	5 (23.8%)	16 (22.8%)	21 (22.8%)	.928
MRI DWI volume ≥100 mL of DWI volume (No.) (%)	4 (19%)	13 (18.6%)	17 (18.7%)	.961
Terminal ICA occlusion (No.) (%)	5 (23.8%)	18 (25.7%)	23 (25.3%)	.961
Proximal M1 occlusion (No.) (%)	5 (23.8%)	21 (30%)	26 (28.6%)	.706
Distal M1 occlusion (No.) (%)	11 (52.4%)	31 (44.3%)	42 (46.1%)	.393