Table 4.
F values for significant main effects of sex on neurotransmitter concentrations for ShA groups (P < 0.05). Arrows indicate the direction of effects of sex compared to males. Degrees of freedom are 1, 26 for all comparisons except the following: amygdala DA, DOPAC, and HVA were 1, 22 for α-PVP, and 1, 24 for 4MMC; degrees of freedom are 1, 25 for 5-HIAA in PFC and NE in striatum for 4MMC; degrees of freedom are 1, 25 for 5-HT, 5-HIAA, and NE in hippocampus, 5-HT, 5-HIAA, DA, DOPAC, and NE in hypothalamus, 5-HT and 5-HIAA in PFC, and NE in striatum for α-PVP.
| Brain Region | 5-HT | 5-HIAA | DA | DOPAC | HVA | NE | GLU |
|---|---|---|---|---|---|---|---|
| α-PVP | |||||||
| Amygdala | ↑ 6.37 | ↑ 6.88 | ↑ 8.16 | ↑ 13.76 | ↓ 41.46 | ||
| Hippocampus | ↑ 19.95 | ||||||
| Hypothalamus | ↑ 6.24 | ↑ 6.84 | |||||
| PFC | ↑ 8.77 | ↑ 10.70 | ↓ 8.48 | ↑ 27.59 | ↑ 49.79 | ||
| Striatum | ↑ 33.11 | ↑ 13.66 | ↑ 5.15 | ↑ 10.86 | |||
| Thalamus | ↑ 29.44 | ||||||
| 4MMC | |||||||
| Amygdala | ↑ 6.21 | ↓ 9.28 | ↑ 16.25 | ↑ 13.10 | ↓ 38.79 | ||
| Hippocampus | ↑ 5.08 | ↑ 27.28 | |||||
| Hypothalamus | ↓ 7.73 | ↑ 15.51 | |||||
| PFC | ↑ 10.17 | ↓ 59.14 | ↑ 30.00 | ↑ 67.07 | |||
| Striatum | ↑ 25.27 | ↑ 33.67 | ↑ 18.25 | ↑ 5.91 | ↑ 6.37 | ||
| Thalamus | ↑ 16.32 | ↓ 7.37 | ↑ 21.04 | ||||