. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: Immunol Rev. 2020 Dec 23;299(1):74–92. doi: 10.1111/imr.12939

Table 1.

Regulatory B cells identified in murine models of cancer

Cancer Type	Surface Markers	Location	Effector Function	Reference
Pancreatic Ductal Adenocarcinoma	CD19⁺CD1d^HiCD5⁺	Tumor	IL-35	69
Pancreatic Ductal Adenocarcinoma	CD19⁺CD1d^HiCD5⁺CD21^Hi	Tumor	IL-35	70, 71, 72
Prostate Cancer	CD20+	Tumor	Lymphotoxin	77
Prostate Cancer	CD19⁺CD20^LoB220^LoIgA⁺PD-L1⁺	Tumor	IL-10	78
Hepatocellular Carcinoma	CD19⁺B220^LoCD138⁺IgA⁺	Tumor	PD-L1	80
Breast Cancer	CD19⁺B220⁺CD25⁺CD69^Hi	Tumor	TGF-B	82
Breast Cancer	PD-L1^Hi CD86^Hi IAd^Hi CD62L^Hi LAP⁺CD44^Lo	Tumor	TGF-B, PD-L1	83
Squamous Carcinoma	CD19⁺CD21^Hi	Tumor	IL-10	85
Non-Hodgkin Lymphoma	CD19⁺CD1d^HiCD5⁺	Tumor	IL-10	86

Instances of regulatory B cells observed in murine models of cancer.