. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: Immunol Rev. 2020 Dec 23;299(1):74–92. doi: 10.1111/imr.12939

Table 2.

Regulatory B cells identified in human cancer

Cancer Type	Surface Markers	Location	Effector Function	Reference
Pancreatic Ductal Adenocarcinoma	CD20⁺	Tumor	IL-35	72
Pancreatic Ductal Adenocarcinoma	CD19⁺CD24^HiCD38^Hi	Peripheral Blood	IL-35, IL-10	71
Hepatocellular Carcinoma	CD19⁺CD5^HiCD27^HiCD38^Dim	Tumor	PD-1, IL-10	81
Oesophageal Carcinoma	CD19⁺CD5⁺	Peripheral Blood	IL-10	157
Ovarian Carcinoma	CD19⁺CD20⁺	Ascites	IL-10	160
Ovarian Carcinoma	CD19⁺	Tumor	Granzyme B	155
Tongue Squamous Carcinoma	CD19⁺	Tumor, Lymph Node	IL-10	20
Gastric Cancer	CD19⁺CD24^HiCD38^Hi	Peripheral Blood, Tumor	IL-10, TGF-β1	161
Gastric Cancer	CD19⁺CD24^HiCD27⁺	Peripheral Blood, Tumor	IL-10	162
Gastric Cancer	CD19⁺	Peripheral Blood	IL-35	101
Breast Carcinoma	CD19⁺	Tumor	Granzyme B	155
Breast Carcinoma	CD19⁺	Tumor	IL-10, CD25	159
Cervical Carcinoma	CD19⁺	Tumor	Granzyme B	155
Head & Neck Squamous Carcinoma	CD19⁺CD24^HiCD38^Hi	Tumor	IL-10, CD25	160
Esophageal Squamous Carcinoma	CD19⁺	Tumor	IL-10, PD-1	161

Instances of regulatory B cells observed in human cancer.