Fig 1.

An example of how the regions of interest were segmented in a left frontal glioblastoma. Four regions of interest (ie, enhancing rim [B and G], cystic cavity [C and H], and immediate [D and I] and distant zones of edema [E and J]) were segmented with contrast-enhanced MPRAGE and T2-weighted images (upper panel) and then were overlaid on FA maps (lower panel). Note that there is a rim of high FA in the immediate zone of edema (arrows in F, G, and J). A circular region of interest is placed on the contralateral NAWM (B and G).