ADC values in the lenticular (A) and caudate (B) nuclei and mIns/NAA ratios on the vermis (C), pulvinar (D), right lenticular nucleus (E), and frontal gray matter (F) in patients with prion disease (p), controls (c), and those with AltD. ADC is decreased and mIns/NAA is increased in patients with prion disease compared with both controls and AltDs. Neither ADC values nor the mIns/NAA ratios can discriminate between the 2 latter groups.