Table 4:

Baseline MRI and clinical markers of patients with and without MSFC progression

	MSFC Nonprogression (Mean)	MSFC Progression (Mean)	P
No. of patients	25	13
ADC histogram markersa
Mean (10−6 m2/s)	0.956 ± 0.021	0.976 ± 0.039	.042
Variance (10−6 m2/s)	0.088 ± 0.008	0.092 ± 0.008	n.s.
Skew	1.035 ± 0.116	0.951 ± 0.193	n.s.
Peak height (10−3)	2.662 ± 0.241	2.539 ± 0.282	n.s.
Peak position (10−6 m2/s)	0.758 ± 0.017	0.768 ± 0.018	n.s.
BPF	0.828 ± 0.040	0.783 ± 0.027	.001b
WMLLperc (%)	3.365 ± 1.673	4.435 ± 2.228	n.s.
Clinical variablesc
Age	36.9 ± 9.2	39.5 ± 11.0	n.s.
Disease duration	6.6 ± 6.6	7.5 ± 7.0	n.s.
Baseline MSFC	0.53 ± 0.46	0.59 ± 0.33	n.s.

Note:—n.s. indicates not significant.

^aAnalysis of covariance with 2-level group factor and age as covariate for MRI variables.

^bP value lower than Bonferroni-corrected .05/7 ∼ .007.

^cTwo-sided t tests for comparison of clinical variables.