Fig 4.
On these inversion-recovery T1-weighted images in which deep gray matter signal is suppressed, the substantia nigra in a patient with severe PD (A) appears both substantially shrunk and with altered contrast in comparison with a healthy control (B). There is a correlation between the substantia nigra area with the Unified Parkinson Disease Rating Scale score.23 There is also a group difference between those with PD and controls; however, this metric has not been proved to be useful for individuals. Images courtesy of Dr Ludovico Minati, Scientific Department, Istituto Di Ricovero e Cura a Carattere Scientifico Foundation Neurologic Institute, Carlo Besta, Milan, Italy.