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Atypical appearance of CNS disease includes T2 hyperintensity localized to the substantia nigra in patient 3 (white arrows, A and B). In patient 7, the facial nerves abnormally enhance bilaterally (white arrows, C) and the left ventral pons has an atypical T2 hyperintense focus (black arrow, D). There is also more ill-defined hyperintensity in the dorsal pons (white arrow, D).
