Table 1.

Diagnosis of Ovarian Cancer Using Tissue Samples Included in the Review

Author	Year	Sample	Preparation	No. of Patients	Method	Spectral Significance
Krishna et al41	2007	Normal, benign, and malignant ovarian tissues	Paraffin -fixed	24	FTIR and Raman spectroscopy	Normal vs malignant: higher protein content and lower DNA and lipid content
				8 normal, 10 benign, 6 malignant		Benign vs malignant: higher protein content and lower DNA and lipid content
Mehrotra et al42	2010	Normal and ovarian cancer tissues	Frozen sections	12	FTIR spectroscopy	Malignant vs normal: higher content of DNA and lipids
						Variations in protein secondary structures
Theophilou et al43	2015	Normal, borderline and malignant ovarian tissues	Paraffin -fixed sections	171	ATR-FTIR spectroscopy	Normal vs malignant: lower lipid/protein ratio, lower phosphate/carbohydrate ratio and higher RNA/DNA ratio
				35 benign, 30 borderline, 106 malignant		Normal vs borderline: lower phosphate/carbohydrate ratio and higher RNA/DNA ratio
						Borderline vs malignant: lower lipid/protein ratio and lower phosphate/carbohydrate ratio
						Normal and benign: similar
Grzelak et al44	2018	Borderline and malignant ovarian tissues	Frozen sections	8	SR-FTIR spectroscopy	Malignant vs borderline: higher content of proteins, DNA and lipids
				1 borderline, 7 malignant
Li et al45	2018	Normal and ovarian cancer cells/tissues	Frozen sections	12	FTIR spectroscopy	Malignant vs normal cell lines: higher content of proteins, variations in protein secondary structures Malignant vs normal tissues: lower content of DNA and lipids
				6 cell lines