Table 1.
Histological Semi-Quantitative Evaluation of Heart Lesions
| Experimental Groups N=5 | Inflammatory Cells (Mean %)** | Fatty Degeneration (Mean %) | Fatty Infiltration* (Mean %) | Vascular Congestion* (Mean %) | Lesion Scoring (0− 100%) |
Lesion Grading |
|---|---|---|---|---|---|---|
| (A) CG† | 2.8% A# | 4.2% A | 5.3% A | 4.7% A | 0–10% | No lesion |
| (B) DOX | 83.7% D | 86.1% D | 92.6% E | 78.3% D | 75–100% | Severe |
| (C) DOX+QC+STN | 48.6% B | 46.2% B | 43.8% B | 49.2% B | 25–50% | Moderate |
| (D) DOX+QC | 60.4% C | 59.5% C | 56.8% C | 71.4% C | 50–75% | Moderate |
| (E) DOX+STN | 55.8% C | 57.4% C | 53.6% C | 68.2% C | 50–75% | Moderate |
Notes: *Area of fatty infiltration and vascular congestion were estimated by (µm). **Each value represents mean ± SDM (n=6). #Statistical comparison among groups: Mean values with different capital letters have significant differences at (P < 0.05). †AControl group; BDoxorubicin group (DOX); CDoxorubicin, Quercetin and Sitagliptin group (DOX+QC+STN); DDoxorubicin and Quercetin group (DOX+QC); EDoxorubicin and Sitagliptin group (DOX+STN).