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Histologic appearance of a cholesteatoma. Hematoxylin-eosin stain. Low-power view (original magnification ×25) (A) and high-power view (original magnification ×400) (B) demonstrate a cystic lesion covered by a strongly keratinizing stratified squamous epithelium (arrows). Within the cyst, there is abundant formation of desquamated keratin lamellas (dashed arrows). Note the prominent strongly hyperchromatic basal layer of the epidermis (thick arrow).
