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Left hemisphere, medial surface. Areas showing a significant cortical thinning in patients with ALS (P < .05) are colored in blue. Areas 1–4 are localized in the frontal region. Areas 7 and 8 are localized in the temporal region. Areas 5 and 6 are localized in the parietooccipital region. CTh in area 8 (inferior temporal and parahippocampal cortex) correlated with the rate of disease progression (P = .0265).
