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Different models of MIRHG splicing and intragenic miRNA biogenesis. (a–c) Synergetic model. (a) Mirtron. (b) Splicing machinery and microprocessors facilitate each other. (c) Splicing factors facilitate miRNA production in a splicing-independent manner. (d,e) Competition model. (d) Alternative-splicing-mediated miRNA production. Two scenarios of alternative splicing are depicted. (e) Nonalternative-splicing-mediated miRNA production
