Table 1.
Optimized once‐daily dosing to maximize EBA(CFU) and minimize Pr(AE) for the total population‐typical, male‐typical, and female‐typical CL‐007 and CL‐010 study participants. Pareto front a cluster exemplars and ranges
| Regimen (mg/day) | Total | Male | Female |
|---|---|---|---|
| C1 | 70 (50, 90) | 70 (50, 90) | 70 (50, 80) |
| C2 | 110 (90, 150) | 110 (90, 150) | 110 (80, 140) |
| C3 | 210 (150, 290) | 210 (150, 280) | 200 (140, 270) |
| C4 | 410 (290, 580) | 400 (280, 560) | 400 (280, 580) |
| C5 | 840 (590, 1200) | 800 (570, 1200) | 840 (590, 1200) |
Ci , i = 1, ..., 5: cluster exemplar label.
Abbreviations: EBA(CFU) early bactericidal activity (colony forming unit); Pr(AE), probability of a drug‐related adverse event.
a
Evolutionary algorithm population size equal to 400.