Table III.
Predictability of different versions of the Caprini score for symptomatic venous thromboembolism (VTE) in patients with COVID-19 by the analysis of receiver operating characteristic (ROC) curve
| Version of the Caprini score | AUC ± SD | P | Cutoff | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|
| Symptomatic VTE during inpatient treatment | |||||
| Caprini[orig:adm] | 0.769 ± 0.090 | .003 | 7 | 73 | 80 |
| Caprini[Dd>ULN:adm] | 0.776 ± 0.096 | .002 | 10 | 73 | 85 |
| Caprini[Dd>3ULN:adm] | 0.757 ± 0.090 | .004 | 7 | 73 | 76 |
| Caprini[COVID-19:adm] | 0.772 ± 0.097 | .003 | 12 | 73 | 84 |
| Caprini[orig:fin] | 0.803 ± 0.095 | .001 | 11 | 73 | 96 |
| Caprini[Dd>ULN:fin] | 0.801 ± 0.100 | .001 | 14 | 73 | 97 |
| Caprini[Dd>3ULN:fin] | 0.797 ± 0.096 | .001 | 11 | 73 | 94 |
| Caprini[COVID-19:fin] | 0.799 ± 0.100 | .001 | 16 | 73 | 97 |
| Symptomatic VTE at 6 months | |||||
| Caprini[orig:fin] | 0.805 ± 0.087 | <.001 | 7 | 75 | 78 |
| Caprini[Dd>ULN:fin] | 0.804 ± 0.092 | <.001 | 10 | 75 | 81 |
| Caprini[Dd>3ULN:fin] | 0.796 ± 0.880 | .001 | 7 | 75 | 75 |
| Caprini[COVID-19:fin] | 0.803 ± 0.092 | <.001 | 12 | 75 | 81 |
AUC, Area under the curve; Caprini[COVID-19:adm], considering two points for asymptomatic infection, three points for symptomatic infection, five points for symptomatic infection with positive D-dimer, score assessed at admission; Caprini[COVID-19:fin], considering two points for asymptomatic infection, three points for symptomatic infection, five points for symptomatic infection with positive D-dimer, score assessed at discharge or death; Caprini[Dd>3ULN:adm], considering three points if D-dimer increased >3 times over ULN, score assessed at admission; Caprini[Dd>3ULN:fin], considering three points if D-dimer increased >3 times over ULN, score assessed at discharge or death; Caprini[Dd>ULN:adm], considering three points if D-dimer increased over ULN, score assessed at admission; Caprini[Dd>ULN:fin], considering three points if D-dimer increased over ULN, score assessed at discharge or death; Caprini[orig:adm], the original score assessed at admission; Caprini[orig:fin], the original score assessed at discharge or death; SD, standard deviation; ULN, upper limit of normal.