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The life cycle of A1M. A1M is primarily synthesized in the liver, from where it is secreted into the blood. It is rapidly equilibrated over the vessel walls of all organs and can be taken up intracellularly. After exerting its functions, it is transported to the kidneys and filtrated in the glomeruli. Finally, it is reabsorbed by the proximal tubular cells where it is degraded together with any bound heme groups and/or radicals.
