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. 2021 Mar 3;12:625780. doi: 10.3389/fphys.2021.625780

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Copyright © 2021 Stanisic, Jeremic, Majumder, Pushpakumar, George, Singh and Tyagi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of HFD and LGG treatment on the molecular remodeling in periodontal tissues. WT, Wild-type C57BJ/L6 mice; HFD, HFD-supplemented wild-type mice; LGG, LGG-supplemented wild-type mice; HFD + LGG, HFD, and LGG-supplemented wild-type mice. Quantitative RT-PCR analysis for (A) TLR₄, (B) TNFα, (C) IL-1β, (D) IL-6, (E) MMP-2, (F) MMP-9, (G) TIMP-2, (H) RANKL, and (I) OPG mRNA expression. The results are presented as the expression of the individual mRNAs with normalization GAPDH, using the 2^−ΔΔCq method. All data represent means ± SD, Fold change vs. WT group. All data represent means ± SD, WT vs. HFD group *p < 0.05; HFD vs. HFD + LGG; ^nsp > 0.05, HFD vs. HFD + LGG ^#p < 0.05, n = 5.