Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 26;78(5):2329–2339. doi: 10.1007/s00018-020-03651-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — The movements of the substrate, uric acid along the translocation pathway. In an equilibrium simulation with the inward-facing ABCG2 structure (PDBID: 6HCO) in the presence of uric acid molecules, a single uric acid molecule entered Site 2′ (a pocket between TM1, TM2, and TM3 in chain B, magenta and violet sticks) from the cytosolic region (black sticks). Uric acid moved forward from Site 2′ (R482′) to Site 3 between TM2, TM2′, TM5, and TM5′, finally to Site 2 at the opposite side in chain A. Line colors of blue-green-yellow–red correspond to uric acid and encode increasing simulation time points; deep purple: N436, F439, T542, and V546; light green: F432, T435, T538, and M549; green: Leu-valve, gray: transmembrane helices; a side view; b top view from the extracellular space