Table 1:

Distinctive features of the 2 main groups of HGG mouse models

Features
Endogenous models (GEMMs and nontargeted mutagenesis/carcinogenesis)
Unpredictable latency periods, growth curves, tumor location, and morphology; implies regular screening for tumor detection and longitudinal monitoring for progression; more physiologic and best representing human disease
Exogenous models or xenografts
Predictable and reproducible, high tumor take; best for high throughput preclinical trials; less physiologic and less representative of the actual human condition