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. 2012 Jan;33(1):24–36. doi: 10.3174/ajnr.A2959

Table 1:

Distinctive features of the 2 main groups of HGG mouse models

Features
Endogenous models (GEMMs and nontargeted mutagenesis/carcinogenesis)
    Unpredictable latency periods, growth curves, tumor location, and morphology; implies regular screening for tumor detection and longitudinal monitoring for progression; more physiologic and best representing human disease
Exogenous models or xenografts
    Predictable and reproducible, high tumor take; best for high throughput preclinical trials; less physiologic and less representative of the actual human condition