Cortical areas >40 mm² with significant differences between patients with Kallmann syndrome and controls by sulcation, curvature, and cortical thickness analyses

Hemisphere	Size (mm2)		Local Maximum, Talairach			FDR Threshold	Cerebral Region
			X	Y	Z
Sulcation
Right	394.05	↓	11.2	13.8	−14.9	3.3429	Olfactory sulcus and contiguous cortex of the rectus gyrus
Right	325.72	↑	16.4	28.7	−23.7	3.3429	Medial orbital-frontal gyrus
Left	518.07	↓	−9.8	16.0	−15.4	3.3159	Olfactory sulcus and contiguous cortex of the rectus gyrus
Left	252.41	↑	−19.6	33.2	−17.3	3.3159	Medial orbital-frontal gyrus
Curvature
Right	372.85	↑	14.4	32.3	−25.3	3.4704	Medial orbital-frontal gyrus
Right	77.61	↓	11.7	16.6	−14.2	3.4704	Olfactory sulcus
Right	44.71	↓	11.5	37.9	−19.1	3.4704	Olfactory sulcus
Left	196.94	↓	−11.6	38.7	−20.0	3.4704	Olfactory sulcus
Left	114.79	↑	−19.6	32.7	−14.9	3.4704	Medial orbital-frontal gyrus
Thickness
Right	568.97	↑	−14.1	30.7	−19.2	3.3834	Olfactory sulcus and contiguous cortex of the rectus and medial orbital-frontal gyri
Left	686.38	↑	13.7	33.4	−23.3	3.2803	Olfactory sulcus and contiguous cortex of the rectus and medial orbital-frontal gyri
Left	78.39	↓	12.7	48.6	33.5	3.2803	Medial orbital-frontal sulcus
Left	40.54	↓	45.2	−62.3	36.9	3.2803	Lateral orbital-frontal gyrus

Note:—↑ indicates that patients with KS showed increased sulcation, curvature, and cortical thickness; ↓, patients with KS showed decreased sulcation, curvature, and cortical thickness; FDR, false discovery rate.