Table 3.
A Receiver Operating Characteristic (ROC) Curve Analysis for Serum Apolipoprotein E and Calcitonin Gene-Related Peptide in Migraine Cases and Controls
| AUC | 95% CI | Cutoff Points | Sen (%) | Spe (%) | PPV (%) | NPV (%) | P value | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Lower | Upper | |||||||||
| Migraine ictal vs interictal | ||||||||||
| CGRP (pg/mL) | 0.708 | 0.471 | 0.946 | 2.08 | 83.3 | 75 | 76.9 | 81.8 | 0.083 | |
| Apolipoprotein E (mg/dl) | 0.528 | 0.287 | 0.768 | 1.59 | 75 | 33.3 | 52.9 | 57.1 | 0.817 | |
| Migraine interictal phase vs control | ||||||||||
| CGRP (pg/mL) | 0.650 | 0.334 | 0.785 | 1.59 | 41.7 | 64.3 | 44.4 | 52.9 | 0.607 | |
| Apolipoprotein E (mg/dl) | 0.920 | 0.804 | 1.000 | 1.20 | 91.7 | 64.3 | 68.8 | 90 | 0.000 | |
| Migraine ictal phase vs control | ||||||||||
| CGRP (pg/mL) | 0.786 | 0.599 | 0.973 | 1.88 | 91.7 | 71.4 | 73.3 | 90.9 | 0.014 | |
| Apolipoprotein E (mg/dl) | 0.908 | 0.782 | 1.000 | 1.39 | 83.3 | 85.7 | 83.3 | 85.7 | 0.000 | |
Abbreviations: AUC, area under curve; CI, confidence interval; Sen, sensitivity; Spe, specificity; PPV, positive predictive value; NPV, negative predictive value; CGRP, calcitonin gene-related peptide.