Table 3.

Predictors of Body Composition in Asthma

Predictors of Skeletal Muscle Mass
Factor	Estimator	Standard Error	P-value
Male sex	2.748 e−02	4.774e−03	<0.001
ACT score	1.186 e−03	5.139 e−04	0.021
Age	−6.497 e−04	1.646 e−04	<0.001
Physical activity	2.913 e−04	2.738 e−05	<0.001
OCS use	−9.242 e−03	6.142 e−03	0.16
ICS dose	−5.031 e−06	5.073e−06	0.40
Intercept	2.748 e−01	1.031e−02	<0.001
Predictors of Fat Mass
Male sex	−7.77 e−02	5.994 e−03	<0.001
ACT score	−1.452 e−03	6.237 e−04	0.021
Age	3.355 e−04	2.089 e−04	0.15
Physical activity	−3.993 e−04	3.419 e−05	<0.001
OCS use	1.369 e−02	9.083 e−03	0.080
ICS dose	6.385 e−05	8.533 e−06	0.38
Intercept	4.292 e−01	1.451 e−02	<0.001

Notes: Multivariate regressions including predictors of SM: multiple R2=0.61, p< 0.0001, and predictors of fat mass: multiple R2=0.61, p< 0.0001. Age in years, sex: being male. In alternative regressions that did not include the ACT score as predictors, OCS use and ICS dose were significant predictors of muscle mass and fat mass (Online Supplementary 3).

Abbreviations: ACT, asthma control test; OCS, regular oral corticosteroid use (categorical variable); physical activity, average daily time in moderate activity in minutes; ICS dose, fluticasone equivalent in µg.