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. 2021 Mar 12;14:1883–1893. doi: 10.2147/OTT.S286666

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© 2021 Deng et al.

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Knocking down HOTAIR inhibited CSCs-like properties, invasion and migration in PDAC.

Notes: Levels of HOTAIR and miR-34a expression were detected via qRT-PCR in CFPAC-1 (A and B) and SW-1990 cells (H and I). Levels of expression of CSCs markers, SOX2, Nanog and Oct4 in CFPAC-1 (C and D) and SW-1990 cells (J and K), were detected via Western blots and qRT-PCR, respectively. (E and L) Cell proliferation detected via CCK-8 assay. (F and M) Detection of sphere formation; spheres (>40 μm in diameter) were counted. (G and N) Detection of invasion and migration of SFM-CFPAC-1 and SFM-SW-1990 cells using the Transwell assay. Error bars: means ± SD (n=3 for each group). *P<0.05; **P<0.01 si-NC or pcDNA3.1-NC group.