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. 2021 Mar 16;12:1689. doi: 10.1038/s41467-021-21989-5

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© The Author(s) 2021, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Hematoxylin and erosion (H&E) staining of rat buccal mucosa tissue after application of different films for 4 h. PVA: poly(vinyl alcohol), DOPA: 3,4-dihydroxy-D-phenylalanine, PLGA: poly(lactic-co-glycolic acid), PDA: polydopamine. Scale bar: 100 μm. b H&E staining of major organs (the heart, liver, spleen, lung, and kidney) after subcutaneous implantation of different films in the backs of Sprague Dawley rats for 1 day. Scale bar: 100 μm. c–f Hematological examination of the variation in WBC (red blood cell count), RBC (white blood cell count), HGB (hemoglobin), and PLT (platelet count) after subcutaneous implantation of different films in the backs of Sprague Dawley rats for 1 or 7 days. g–n Blood biochemistry examination of the variation in Mg²⁺, Ca²⁺, CK (creatine kinase), LDH-L (lactate dehydrogenase), ALT (alanine transferase), AST (aspartate transferase), BUN (blood urea nitrogen), and CREA (creatinine) after subcutaneous implantation of different films in the backs of Sprague Dawley rats for 1 or 7 days. All data are Mean ± S.D. n = 3 animals per group. Statistics was calculated by one-way ANOVA followed by Tukey’s post-test. Source data are provided as a Source data file.