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. 2021 Mar 12;16:2107–2121. doi: 10.2147/IJN.S295565

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© 2021 Zhao et al.

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(A) Hematoxylin & eosin analysis of major organs of mice (heart, liver, spleen, lung, and kidney) and tumors under different treatments (PBS, DTIC, aPD1, DTIC@MSN, DTIC@CMSN, DTIC@CMSN+aPD1). Magnification 200×. (B) Serum levels of blood count (red blood cells (RBC), white blood cells (WBC), platelets (PLT) and hemoglobin (HGB)). (C) Serum levels of liver function biomarkers.

Abbreviations: ALT, alanine transaminase; LDH, lactate dehydrogenase; AST, aspartate aminotransferase; CRE, renal function creatinine; BUN, blood urea nitrogen; UA, urea.