Characteristics of patients with CADASIL and healthy controls
| Patients with CADASIL (n = 22) | Healthy Controls (n = 29) | P Value | |
|---|---|---|---|
| Age (yr) (mean) (range) | 53.5 ± 11.1, 32.1–74.5 | 53.8 ± 11.0, 30.1–71.4 | .73 |
| Male sex (No.) (%) | 11/22 (50%) | 15/29 (52%) | .88 |
| Right-handed (No.) (%) | 22/22 (100%) | 28/29 (97%) | .99 |
| Level of education (yr) | 11.7 ± 3.9 | 13.6 ± 3.5 | .08 |
| MMSE (mean) (median) (range) | 28.5, 29, 25–30 | 29.0, 29, 26–30 | .26 |
| Brain volume in mm3 (mean) | 1017202 ± 113233 | 1003640 ± 84340 | .64 (.61)a |
| Normalized GM peak (mean) | 0.30 ± 0.05 | 0.31 ± 0.05 | .48 (.45)a |
| Normalized WM peak (mean) | 0.59 ± 0.06 | 0.67 ± 0.09 | .001 (.001)a |
| Contrast between GM and NAWM (mean) | 1.35 ± 0.08 | 1.43 ± 0.04 | .001 (<10−5)a |
| White matter lesion volume, (mean) (median) (range) in mm3 | 97972.9, 76256.6, 7249.8–267095.1 | NA | – |
| Lacunar lesion volume (mean) (median) (range) in mm3 (n = 14/22, 64%)b | 526.1, 290.1, 14.0–1974.7 | NA | – |
| No. of microhemorrhages (mean) (median) (range) (n = 8/22, 36%)b | 6.5, 2.5, 1–32 | NA | – |
Note:—NA indicates not applicable; –, no test performed.
a
P value adjusted for age and sex.
b
In patients with such lesions (number given in parentheses).