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. 2021 Mar 3;11:614665. doi: 10.3389/fcimb.2021.614665

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Copyright © 2021 Talavera-López, Messenger, Lewis, Yeo, Reis-Cunha, Matos, Bartholomeu, Calzada, Saldaña, Ramírez, Guhl, Ocaña-Mayorga, Costales, Gorchakov, Jones, Nolan, Teixeira, Carrasco, Bottazzi, Hotez, Murray, Grijalva, Burleigh, Grisard, Miles and Andersson

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Bayesian principal component analysis (PCA) of T. cruzi TcI strains using INDELs. The percentage of variance for PC1 was 46.2 and for PC2 28.6. (B) Identity by Descent (IBD) dendogram of T. cruzi TcI strains using SNPs, calculated using 1000 bootstraps. Both analyses, using different markers, support the population structure of the analyzed TcI samples. Notably, the highly virulent TcI Colombiana and the Panamanian TcI H1 from a chronic patient are presented as outliers [(B), far left].