Fig 4.

Age-related change in the rGMC extracted from MR imaging versus that from I-123 iomazenil BP uncorrected for PVE is indicated in the scatterplot graph (A). The data were evaluated by using a VOI analysis based on the AAL atlas, composed of 116 VOIs. For each VOI, the ratio of the group-averaged parameter for the young subjects to that for the elderly subjects is plotted. SPM analysis based on a multiple regression model for PVE-uncorrected SPECT images (B1) and for rGMC (B2) shows clusters of voxels with significant age-related decreases in the parameters.