Table 2.
Antifungal treatment in 11 dogs with sporotrichosis assisted at INI/Fiocruz, Rio de Janeiro, Brazil, and the corresponding MIC values according to the antifungal susceptibility tests from their isolates
| Isolate code | Species determined by molecular tests | Initial therapeutic scheme | Change of therapeutic scheme | Treatment time to clinical cure (weeks) | MIC (μg/ml) | ||||
|---|---|---|---|---|---|---|---|---|---|
| AMB | KTZ | ITZ | TRB | POS | |||||
| 24C | S. schenckii | KTZ 200 mg/dog q24h | ITZ 250 mg/dog q24h | 24 | 8.00 | 0.50 | 0.50 | 0.06 | 0.50 |
| 10C | S. brasiliensis | ITZ 100 mg/dog q24h | – | 32 | 4.00 | 0.25 | 0.50 | 0.06 | 0.50 |
| 12C | S. brasiliensis | ITZ 200 mg/dog q24h | – | – | 2.00 | 0.50 | 0.50 | 0.03 | 0.50 |
| 13C | S. brasiliensis | ITZ 200 mg/dog q24h | ITZ 300 mg/dog q24h | 44 | 8.00 | 0.50 | 0.50 | 0.12 | 1.00 |
| 14C | S. brasiliensis | ITZ 300 mg/dog q24h | – | 32 | 2.00 | 0.06 | 0.25 | 0.06 | 0.25 |
| 16C | S. brasiliensis | ITZ 100 mg/dog q24h | – | 56 | 2.00 | 0.25 | 0.25 | 0.06 | 1.00 |
| 17C | S. brasiliensis | – | – | – | 2.00 | 0.50 | 0.25 | 0.12 | 0.50 |
| 18C | S. brasiliensis | ITZ 200 mg/dog q24h | – | 20 | 1.00 | 0.25 | 0.25 | 0.06 | 0.50 |
| 21C | S. brasiliensis | KTZ 100 mg/dog q24h | ITZ 150 mg/dog q24h | – | 2.00 | 0.50 | 0.25 | 0.06 | 0.50 |
| 22C | S. brasiliensis | ITZ 200 mg/dog q24h | ITZ 300 mg/dog q24h | – | 2.00 | 0.12 | 0.12 | 0.50 | 0.25 |
| 23C | S. brasiliensis | ITZ 150 mg/dog q24h | – | 76 | 2.00 | 0.50 | 0.50 | 0.06 | 0.50 |
MIC minimum inhibitory concentration, AMB amphotericin B, KTZ ketoconazole, ITZ itraconazole, POS posaconazole, TRB terbinafine, – not applicable