Table 4.
p16INK4a and NF-κB immunoreactivity among different anatomical sites of HPV-positive and -negative HNSCC tumors
| HPV-DNA (+) | HPV-DNA (−) | HPV-DNA (+) | HPV-DNA (−) | HPV-DNA (+) | HPV-DNA (−) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p16INK4a (+) n (%) | p16INK4a (−) n (%) | p16INK4a (+) n (%) | p16INK4a (−) n (%) | High cytoplasmic NF-κB expression n (%) | Low cytoplasmic NF-κB expression n (%) | High cytoplasmic NF-κB expression n (%) | Low cytoplasmic NF-κB expression n (%) | High nuclear NF-κB expression n (%) | Low nuclear NF-κB expression n (%) | High nuclear NF-κB expression n (%) | Low nuclear NF-κB expression n (%) | |
| Tongue | 5 (83.3) | 1 (16.7) | 4 (12.5) | 28 (87.5) | 3 (50) | 3 (50) | 23 (74.2) | 8 (25.8) | 1 (16.7) | 5 (83.3) | 4 (12.9) | 27 (87.1) |
| Oral Cavity | 6 (75) | 2 (25) | 7 (36.8) | 12 (63.2) | 7 (87.5) | 1 (12.5) | 18 (75) | 6 (25) | 1 (12.5) | 7 (87.5) | 7 (29.2) | 17 (70.8) |
| Larynx | 3 (75) | 1 (25) | 1 (14.3) | 6 (85.7) | 4 (100) | 0 (0) | 5 (62.5) | 3 (37.5) | 2 (50) | 2 (50) | 2 (25) | 6 (75) |
| Hypopharynx | 0 (0) | 2 (100) | 1 (14.3) | 6 (85.7) | 1 (100) | 0 (0) | 5 (71.4) | 2 (28.6) | 1 (100) | 0 (0) | 4 (57.1) | 3 (42.9) |
| Nasopharynx | 2 (100) | 0 (0) | 0 (0) | 5 (100) | 1 (50) | 1 (50) | 3 (60) | 2 (40) | 0 (0) | 2 (100) | 1 (20) | 4 (80) |
| Tonsil | 3 (100) | 0 (0) | 0 (0) | 2 (100) | 2 (66.7) | 1 (33.3) | 1 (50) | 1 (50) | 0 (0) | 3 (100) | 1 (50) | 1 (50) |
| Total | 19 (76) | 6 (24) | 13 (18) | 59 (82) | 18 (75) | 6 (25) | 55 (71.4) | 22 (28.6) | 5 (20.8) | 19 (79.2) | 19 (24.7) | 58 (75.3) |