Table 3.
Univariable and multivariable analyses for risk factors of relapse and survival.
| Parameters | Relapse | Overall survival | Leukemia-free survival | GVHD-free/relapse-free survival (GRFS) | ||||
|---|---|---|---|---|---|---|---|---|
| Univariable P value | Multivariable P value;HR (95% CI) | Univariable P value | Multivariable P value;HR (95% CI) | Univariable P value | Multivariable P value; HR (95% CI) |
Univariable P value | Multivariable P value; HR (95% CI) |
|
| Female vs. male | 0.160 | – | 0.866 | – | 0.627 | – | 0.283 | – |
| Patient age ≥29 vs. <29 years (median) |
0.207 | – | 0.133 | – | 0.172 | – | 0.111 | – |
| Disease category AML vs. ALL vs. ABL |
0.644 | – | 0.759 | – | 0.657 | – | 0.736 | – |
| Genetic status Other vs. unfavorable |
0.201 | – | 0.451 | – | 0.318 | – | 0.253 | – |
| BM blasts on day 0 ≥3% vs. <3% (median) |
*0.001 | *0.001; 4.340 (2.359–7.987) |
*0.001 | *0.001; 2.861 (1.744–4.693) |
*0.001 | *0.001; 3.016 (1.843–4.936) |
*0.001 | *0.001; 3.656 (2.328–5.743) |
| Transplant modality HID vs. MSD/MUD |
*0.040 | *0.038; 0.476 (0.237–0.959) |
0.125 | – | 0.061 | 0.076; 0.610 (0.354–1.053) |
0.222 | – |
| Strategy of pDLI modified vs. previous |
0.456 | – | 0.863 | – | 0.666 | – | *0.044 | *0.010; 0.459 (0.292–0.722) |
| Number of pDLI 0 vs. 1 vs. >1 |
0.552 | – | 0.514 | – | 0.375 | – | 0.776 | – |
| aGVHD II–IV vs. 0–I |
0.359 | – | * 0.012 | 0.061; 1.604 (0.978–2.630) |
*0.023 | 0.096; 1.517 (0.928–2.480) |
*0.009 | *0.020; 1.679 (1.086–2.596) |
| cGVHD vs. No cGVHD | *0.030 | *0.041; 0.526 (0.294–0.939) |
*0.002 | *0.002; 0.454 (0.279–0.739) |
*0.005 | *0.010; 0.524 (0.321–0.855) |
0.677 | – |
AML, acute myeloid leukemia; ALL, acute lymphoblastic leukemia; ABL, acute biphenotypic leukemia; BM, bone marrow; HID, HLA-haploidentical related donor; MSD, HLA-matched sibling donor; MUD, HLA-matched unrelated donor; pDLI, prophylactic donor lymphocyte infusion; aGVHD, acute graft-versus-host disease; cGVHD, chronic graft-versus-host disease; HR, hazard risk; CI, confidence interval; *P < 0.05.