Table 1.

Cohort characteristics.

Variable	PDD cases (n = 9)	Controls (n = 9)	P-value
Male sex, n (%)	5 (55.5)	4 (44.4)	0.7
Age	78 (66–93)	87 (79–95)**	0.005
PMD (hours)	27 (9–48)	25 (15–48)	0.8
α-synuclein Braak	6 (5–6)	0****	<0.0001
tau Braak	2 (0–4)	2 (1–3)	0.9
Thal	2 (0–5)	2.5 (0–1)	0.4
CERAD	0 (0–2)	0 (0–1)	0.7
Disease duration (years)	13 (6–23)	N/A	N/A
Age onset	67 (49–69)	N/A	N/A
Whole brain weight (g)	1371 (960–1402)	1126 (946–1338)	0.0503
Never smoked, n (%)	4 (44.4)	2 (22.2)	0.3

Comparison of PDD case and control variables. All variables are medians (range); p-values for significance of between-group differences were calculated by Mann-Whitney U test.

^**p < 0.01;

^****p < 0.0001. CERAD, The Consortium to Establish a Registry for Alzheimer's disease score; PMD, post-mortem delay. Significant case-control differences are highlighted in bold.